The SMP team welcomes Mathieu Soetens (from Prof. Olivier Riant lab, UCLouvain, Belgium) who will be spending the next two monthes with us.
In our research team, we are mainly interested by "molecular programming" with the aim to explore or manipulate complex biological systems such as living cells or organisms. In other words, we design molecules that have built into their structure a chemical program enabling them to perform specific tasks autonomously within biological environments. Recently, we developed various molecular devices programmed for the selective delivery of anticancer drugs. These functional systems include programming components like self-immolative linkers, chemical amplifiers, self-opening macrocycles, etc... that pilot the process of drug release in a stringently controlled fashion.
Professor Sébastien Papot was elected among the six « Poitevins » of 2017 in the « research category ».
Read our two new articles in Journal of proteomics: « Study of a novel agent for TCA precipitated proteins washing – comprehensive insights into the role of ethanol/HCl on molten globule state by multi-spectroscopic analyses » Balkis Eddhif, Justin Lange, Nadia Guignard, Yann Batonneau, Jonathan Clarhaut, Sébastien Papot, Claude Geffroy-Rodier, Pauline Poinot, J. Prot., 2017, DOI: http://sci-hub.tw/10.1016/j.jprot.2017.11.016
Journal of control release: « Enhancing tumor response to targeted chemotherapy through up-regulation of folate receptor α expression induced by dexamethasone and valproic acid »Péraudeau E., Cronier L., Monvoisin A., >Poinot P., Mergault C., Guilhot F., Tranoy-OpalinskiI., Renoux B.,Papot S., Clarhaut J. J. Cont. Rel., 2017, DOI: 10.1016/j.jconrel.2017.11.011
Read our new article : Development and evaluation of β-galactosidase-sensitive antibody-drug conjugates,
Sergii Kolodych, Chloé Michel, Sébastien Delacroix, Oleksandr Koniev, Anthony Ehkirch, Jitka Eberova, Sarah Cianférani, Brigitte Renoux, Wojciech Krezel, Pauline Poinot, Christian D.Muller, Sébastien Papot, Alain Wagner
Read our new article in Chemical Science : In situ targeted activation of an anticancer agent using ultrasound-triggered release of composite droplets,