Publications

Last publications of the SMP team

47– « Development and evaluation of β-galactosidase-sensitive antibody-drug conjugates »Sergii Kolodych, Chloé Michel, Sébastien Delacroix, Oleksandr Koniev, Anthony Ehkirch, Jitka Eberova, Sarah Cianférani, Brigitte Renoux, Wojciech Krezel, Pauline Poinot, Christian D.Muller, Sébastien Papot, Alain Wagner Eur. J. Med. Chem., 2017, DOI: 10.1016/j.ejmech.2017.08.008

Eur. J. Med. Chem 08-2017

Eur. J. Med. Chem 08-2017

46– “In situ targeted activation of an anticancer agent using ultrasound-triggered release of composite droplets“ Marine Bezagu, Jonathan Clarhaut, Brigitte Renoux, Fabrice Monti, Mickael Tanter, Patrick Tabeling, Janine Cossy, Olivier Couture, Sebastien Papot, and Stellios Arseniyadis Eur. J. Med. Chem., 2017, DOI: 10.1016/j.ejmech.2017.03.057

Eur. J. Med. Chem. 2017

45– “Targeting the Tumour Microenvironment with Enzyme-Responsive Drug Delivery System for Efficient Therapy of Breast and Pancreatic Cancers“ Brigitte Renoux, Florian Raes, Thibaut Legigan, Elodie Péraudeau, Balkis Eddhif, Pauline Poinot, Isabelle Tranoy-Opalinski, Jérôme Alsarraf, Oleksandr Koniev, Sergii Kolodych, Stéphanie Lerondel, Alain Le Pape, Jonathan Clarhaut, and Sébastien Papot Chem. Sci. , 2017, DOI: 10.1039/C7SC00472A

Chem Sci 2017 bis

Chem Sci 2017

43– “Rotaxane-based architectures for biological applications“ N. Pairault, R. Barat, I. Tranoy-Opalinski, B. Renoux, M. Thomas, S. Papot Comptes Rendus de chimie. 2016, 19, 1-2, 103-112

42– “A Dendritic b-Galactosidase-Responsive Folate-Monomethylauristatin E Conjugate” J. Alsarraf, E. Péraudeau, P. Poinot, I. Tranoy-Opalinski, J. Clarhaut, B. Renoux and S. Papot Chem. Commun. 2015, Advance Article

Chem. Commun.

Chem. Commun.

41– “A mechanically interlocked molecular system programmed for the delivery of an anticancer drug” R. Barat, T. Legigan, I. Tranoy-Opalinski, B. Renoux, E. Péraudeau, J. Clarhaut, P. Poinot, A. E. Fernandes, V Aucagne, D. A. Leigh and S. Papot, Chem Sci. 2015, 6, 2608-2613

Chem Sci.

Chem Sci.

40– “Surface functionalization by covalent immobilization of an innovative carvacrol derivative to avoid fungal biofilm formation” A. Gharbi, T. Legigan, V. Humblot, S. Papot and J.-M. Berjault ABM Express 2015

39– “Evaluation of cytotoxic properties of a cyclopamine glucuronide prodrug in rat glioblastoma cells and tumors” S. Bensalma, C. Chadeneau, T. Legigan, B. Renoux, A. Gaillard, M. De Boisvilliers, C. Pinet-Charvet, S. Papot and J.-M. Muller J. Mol. Neurosci. 2015, 55, 51-61.

38– “Synthesis of Benzohydroxamic Acids Glucosides and Galactosides” M. Thomas, I. Tranoy-Opalinski, B. Renoux, T. Chalopin and S. Papot Carbohydrate Chemistry: Proven Synthetic Method 2015,Volume 3, Chapter 20, 159-169

37– “Selective release of a cyclopamine glucuronide prodrug towards stem-like cancer cell inhibition in glioblastoma” A. Balbous, B. Renoux, U. Cortes, S. Milin, K. Guilloteau, T. Legigan, P. Rivet, O. Boissonnade, S. Martin, C. Tripiana, M. Wager, R.-J. Bensadoun, S. Papot, and L. Karayan-Tapon Mol. Cancer Ther. 2014, 13, 2159-2169.

36– “ß-Glucuronidase-Responsive Prodrugs for Selective Cancer Chemotherapy: an Update.” I. Tranoy-Opalinski, T. Legigan, R. Barat, J. Clarhaut, M. Thomas, B. Renoux and S. Papot, Eur. J. Med. Chem. 2014, 74, 302-313.

J. Med. Chem.

J. Med. Chem.

 

35– “An Enzyme-Responsive System Programmed for the Double Release of Bioactive Molecules through an Intracellular Chemical Amplification Process” M. Grinda, T. Legigan, J. Clarhaut, E. Peraudeau, I. Tranoy-Opalinski, B. Renoux, M. Thomas, F. Guilhot and S. Papot, Org. Biomol. Chem. 2013, 11, 7129-7133.

Org. Biomol. Chem.

Org. Biomol. Chem.

34– “Synthesis and biological evaluations of a monomethylauristatin E glucuronide prodrug for selective cancer chemotherapy” T. Legigan, J. Clarhaut, B. Renoux, I. Tranoy-Opalinski, A. Monvoisin, C. Jayle, J. Alsarraf, M. Thomas and S. Papot, Eur. J. Med. Chem. 2013, 67, 75-80.

J. Med. Chem.

J. Med. Chem.

 

33– “Oxidative decarboxylation of diclofenac by manganese oxide bed filter” M. Huguet, M. Deborde, S.  Papot, H. Gallard, Water Res. 2013, 47, 5400-5408.

Water Res.

Water Res.

 

32– “A Galactosidase-Responsive Doxorubicin-Folate Conjugate for Selective Targeting of Acute Myelogenous Leukemia Blasts” J. Clarhaut, S. Fraineau; J. Guilhot; E. Peraudeau, I. Tranoy-Opalinski, M. Thomas, B. Renoux, E. Randriamalala, P. Bois, A. Chatelier, A. Monvoisin, L. Cronier, S. Papot and F. Guilhot, Leukemia Res. 2013, 37, 948-955.

 

31– “NDMA Formation by Chloramination of Ranitidine: Kinetics and Mechanism” J. Le Roux, E. Gallard, J.-P. Croue, S. Papot and M. Deborde,Environ. Sci. Eng. 2012, 46, 11095-11103.

Environ. Sci. Eng.

Environ. Sci. Eng.

30– “The First Generation of ß-Galatosidase-Responsive Prodrugs Designed for the Selective Treatment of Solid Tumors in Prodrug Monotherapy” T. Legigan, J. Clarhaut, I. Tranoy-Opalinski, A. Monvoisin, B. Renoux, M. Thomas, A. Le Pape, S. Lerondel and S. Papot Angew. Chem. Int. Ed. 2012, 51, 11606-11610. (“Very Important Paper”, Inside Cover)

 

Angew. Chem. Int. Ed.

Angew. Chem. Int. Ed.

 

29- “Gas Chromatography-Mass Spectrometry of hexafluoroacetone derivatives: first time utilization of a gaseous phase derivatizing agent for analysis of extraterrestrial amino acids” C. Geffroy-Rodier, A. Buch, R. Sternberg and S. Papot J. Chromatogr. A 2012, 1245, 158-166.

 

28- “Synthesis and Antitumor Efficacy of a ß-Glucuronidase-Responsive Albumin-Binding Prodrug of Doxorubicin” T. Legigan, J. Clarhaut,B. Renoux, I. Tranoy-Opalinski, A. Monvoisin, J.-M. Berjeaud, F. Guilhot and S. Papot J. Med. Chem. 2012, 55, 4516-4520.

J. Med. Chem.

J. Med. Chem.

 

27– “Second Generation Specific-Enzyme-Activated Rotaxane Propeptides” A. Fernandes, A. Viterisi,V. Aucagne, D. A. Leigh and S. Papot Chem. Commun. 2012, 48, 2083-2085.

Chem. Commun.

Chem. Commun.

 

26- “Formal synthesis of TMC-69-6H via a one-pot enantioselective domino proline-mediated aldol/olefin homologation procedure” S. Vuong, N. Brondel, C. Len, S. Papot and B. Renoux Tetrahedron 2012, 68, 433-439.

Tetrahedron

Tetrahedron

 

 

25- “A self-immolative dendritic glucuronide prodrug of doxorubicin” M. Grinda, J. Clarhaut, B. Renoux, I. Tranoy-Opalinski and S. Papot MedChemComm 2012, 3, 68-70.(“Hot paper”)

MedChemCom

MedChemCom

 

24– “A Heterodimeric Glucuronide Prodrug for Cancer Tritherapy: the Double Role of the Chemical Amplifier” M. Grinda, J. Clarhaut, I. Tranoy-Opalinski, B. Renoux, A. Monvoisin, L. Cronier and S. Papot ChemMedChem 2011, 6, 2137-2141. (Inside Cover)

MedChemCom

MedChemCom

 

23- “A new cyclopamine glucuronide prodrug with improved kinetics of drug release” B. Renoux, T. Legigan, S. Bensalma, C. Chadéneau, J.-M. Muller and S. Papot Org. Biomol. Chem. 2011, 9, 8459-8464.

Org. Biomol. Chem.

Org. Biomol. Chem.

22– “A Galactosidase-Responsive “Trojan Horse” for the Selective Targeting of Folate Receptor-Positive Tumor Cells” M. Thomas, J. Clarhaut, P.-O. Strale, I. Tranoy-Opalinski, Joëlle Roche and S. Papot ChemMedChem 2011, 6, 1006-1010.

ChemMedChem

ChemMedChem

 

 

21– “Dietary lipid-induced sensitization of tumors to locally delivered drug” S. Chevalier, C. Goupille, K. Mahéo, I. Domingo, C. Dussiau, B. Renoux, P. Bougnoux, S. Papot Clin. Lipidol. 2010, 5, 233-243.

 

20– “Study of a Cyclopamine Glucuronide Prodrug for the Selective Chemotherapy of Glioblastoma” F. Hamon, B. Renoux, C. Chadéneau, J.-M. Muller and S. Papot  Eur. J. Med. Chem. 2010, 45, 1678-1682.

Eut. J. Med. Chem.

Eut. J. Med. Chem.

 

19– “Cyanuric Chloride: an Efficient Reagent for the Lossen Rearrangement” F. Hamon, G. Prié, F. Lecornué and S. Papot Tetrahedron Lett. 2009, 50, 6800-6802.

Tetrahedron Lett.

Tetrahedron Lett.

 

18– “Rotaxane-Based Propeptides: Protection and Enzymatic Release of a Bioactive Pentapeptide” A. Fernandes, A. Viterisi, F. Coutrot, S. Potok, D. A. Leigh, V. Aucagne, and S. Papot Angew. Chem. Int. Ed. 2009, 48,6443-6447. (“Hot Paper”)

Angew. Chem. Int. Ed.

Angew. Chem. Int. Ed.

17– “Synthesis and Biological Evaluation of Glucuronide Prodrugs of the Histone Deacetylase Inhibitor CI-994 for Application in Selective Cancer Chemotherapy” M. Thomas, J. Clarhaut, I. Tranoy-Opalinski, J.-P. Gesson, J. Roche and S. Papot Bioorg. Med. Chem. 2008, 16, 8109-8116.

Bioorg. Med. Chem.

Bioorg. Med. Chem.

16– “Design of Self-Immolative Linkers for Tumour-Activated Prodrug Therapy” I. Tranoy-Opalinski, A. Fernandes, M. Thomas, J.-P. Gesson and S. Papot Anti-Cancer Agents Med. Chem. 2008, 8, 618-637 (review article).

 

15– “First O-Glycosylation of Hydroxamic Acids” M. Thomas, J.-P. Gesson and S. Papot J. Org. Chem. 2007, 72, 4262-4264.

J. Org. Chem.

J. Org. Chem.

 

14– “Synthesis and Biological Evaluation of the Suberoylanilide Hydroxamic Acid (SAHA) ß-glucuronide and ß-galactoside for Application in Selective Prodrug Chemotherapy” M. Thomas, F. Rivault, I. Tranoy-Opalinski, J. Roche, J.-P. Gesson and S. Papot Bioorg. Med. Chem. Lett. 2007, 17, 983-986.

Bioorg. Med. Chem. Lett.

Bioorg. Med. Chem. Lett.

13– “Efficient regio and stereoselective Synthesis of 1-ß-O-Glucuronyl Carbamates and Carbonates from 1,2,3,4-Hydroxyl Unprotected Glucuronates” M. Thomas, J.-P. Gesson and S. Papot Synlett 2007, 12, 1966-1968.

 

12– “A New Simple and Convenient Method for the Synthesis of Substituted 2,6,9-Trioxabicyclo[3.3.1]-nona-3,7-dienes from Arylmalondialdehydes” A. Fernandes, J. Marrot, J.-P. Gesson and S. Papot Tetrahedron Lett. 2006, 47, 5961-5964.

Tetrahedron Lett.

Tetrahedron Lett.

11– “Looking Forward: A Glance into the Future of Organic Chemistry” P. Compain, V. Desvergnes, C. Ollivier, F. Robert, F. Suzenet, M. Barboiu, P. Belmont, Y. Blériot, F. Bolze, S. Bouquillon, E. Bourguet, B. Braida, T. Constantieux, L. Désaubry, D. Dupont, S. Gastaldi, F. Jérome, S. Legoupy, X. Marat, M. Migaud, N. Moitessier, S. Papot, F. Péri, M. Petit, S. Py, E. Schulz, I. Tranoy-Opalinski, B. Vauzeilles, P. Vayron, L. Vergnes, S. Vidal et S. Wilmouth New J. Chem. 2006, 30, 823-831.

New J. Chem.

New J. Chem.

 

10– “Alchimies futures : compte rendu de l’expérience ESYOP” P. Compain, V. Desvergnes, C. Ollivier, F. Robert, F. Suzenet, M. Barboiu, P. Belmont, Y. Blériot, F. Bolze, S. Bouquillon, E. Bourguet, B. Braida, T. Constantieux, L. Désaubry, D. Dupont, S. Gastaldi, F. Jérome, S. Legoupy, X. Marat, M. Migaud, N. Moitessier, S. Papot, F. Péri, M. Petit, S. Py, E. Schulz, I. Tranoy-Opalinski, B. Vauzeilles, P. Vayron, L. Vergnes, S. Vidal et S. Wilmouth C. R. Chimie 2006, 9, 127-140.

Chimie

Chimie

 

09– “Synthesis and Evaluation of ß-D-Glucopyranosiduronic Analogues as New Triggers for b-Glucuronidase Mediated Prodrug Mono-therapy” D. Combaud, M. Thomas, S. Papot and J.-P. Gesson Lett. Drug Des. Discov. 2005, 8, 631-637.

 

08– “Design of Selectively Activated Anticancer Prodrugs: Elimination and Cyclisation Strategies” S. Papot, I. Tranoy, F. Tillequin, J.-C. Florent and J.-P.Gesson Current Medicinal Chemistry – Anticancer Agents 2002, 2, 155-185 (review article).

 

07– “A Model of Alcohol Prodrug for Glucuronidase Mediated Cancer Chemotherapy” S. Papot., I. Tranoy, F. Rivault and J.-P.Gesson Synlett 2002, 1, 164-166.

 

06– “Agressive Behavior Induced by the Steroid Sulfatase Inhibitor Coumate and by DHEAS in CBA/H mice” B. Nicolas, W. Pinoteau, S. Papot, S. Routier, G. Guillaumet and S. Morteau Brain Res. 2001, 922, 216-222.

Brain Res.

Brain Res.

 

05– “Synthesis of Indomethacin Analogues for Evaluation as Moderators of MRP” A. R. Maguire, S. J. Plunkett, S. Papot, M. Clynes, R. O’Connor and S. Touhey. Bioorg. Med. Chem. 2001, 9, 745-762.

Bioorg. Med. Chem.

Bioorg. Med. Chem.

04– “Enantioselective Synthesis of Sulindac” A. R. Maguire, S. Papot, A. Ford, S. Touhey, R. O’Connor and M. Clynes Synlett 2001, 1, 41-44.

 

03– “Synthesis and Cytotoxic Activity of a Glucuronylated Prodrug of Nornitrogen Mustard” S. Papot, D. Combaud, K. Bosslet, M. Gerken, J. Czech and J.-P. Gesson Bioorg. Med. Chem. Lett. 2000, 10, 1835-1837.

 

02– “Study of Biscarbamates Derived from 2-Aminobenzylamines as Models for Alcohol Prodrugs” S. Papot, C. Bachman, D. Combaud and J.-P. Gesson Tetrahedron 1999, 55, 4699-4708.

Tetrahedron

Tetrahedron

 

01– “A New Spacer Group from Arylmalonaldehydes for Glucuronylated Prodrugs” S. Papot, D. Combaud and J.-P. Gesson Bioorg. Med. Chem. Lett. 1998, 8, 2545-2548.

Bioorg. Med. Chem. Lett.

Bioorg. Med. Chem. Lett.